Arizona's injury-riddled secondary tests the coaching staff as Will Johnson's groin status remains uncertain after Week 2. The Cardinals have also lost Max Melton, Garrett Williams, Sean Murphy-Bunting, and Starling Thomas, with Walter Nolen sidelined for at least four weeks. A brutal stretch ahead includes a road game at San Francisco followed by a Thursday night showdown with Seattle, forcing rookies to step up quickly.

Kyler Murray emphasized readiness and resilience, underscoring the domino effect of the injuries. For fantasy managers, monitor practice reports for depth chart shifts and potential increases in targets or role changes in the secondary as Arizona looks to weather the storm.

Bills sit No. 1 with a clean Week 2 showing, followed by Eagles, Ravens, Packers, and Chargers as Week 3 favorites. The rest of the league shifts with the Dolphins and Panthers sliding after rough outings, while Colts climb into the middle of the pack on explosive offense and emerging pieces. Bryce Young flashed in Carolina, Spencer Rattler impressed in New Orleans, and J.J. McCarthy looks like a work-in-progress in Minnesota as teams settle into schemes and fantasy roles.